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. 2023 May 18;15(1):2211923. doi: 10.1080/19490976.2023.2211923

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — Alpha-diversity of each diagnostic group. The alpha diversity is determined using a) ASV richness, b) Shannon diversity index, and c) Faith’s Phylogenic Diversity. P-values are based on linear mixed effect models, with sibling pairs as random effects and pairwise testing adjusted for multiple comparisons using Tukey’s method. Cases were compared to non-affected siblings and non-related children, while non-affected siblings were compared to non-related children.