Table 2.
Vaccine Efficacy and Effectiveness by Vaccine type and variant
| Efficacy or Effectiveness | Categories by vaccine or variant | No. Studies (Sample Size) | Pooled Efficacy | Between studies, heterogeneity assessment (%) | |
|---|---|---|---|---|---|
|
P | ||||
| 1st Dose Efficacy | Astra |
5 (634,638) |
0.78 (0.62, 0.95) | 77.09% | 0.001 |
| Pfizer |
3 (733,805) |
0.84 (0.77, 0.92) | 89.97% | 0.001 | |
| 2nd Dose Efficacy | Astra | 11 (92,653) | 0.67 (0.54, 0.80) | 79.99% | 0.001 |
| Pfizer | 2 (113,651) | 0.93 (0.85, 1.00) | - | - | |
| Baharat |
5 (70,028) |
0.71 (0.61, 0.82) | 88.30% | 0.001 | |
| SARS COV2 |
1 (277) |
0.70 (0.65, 0.76) | - | - | |
| 1st Dose Effectiveness | Moderna |
9 (117,034) |
0.74 (0.65, 0.83) | 75.08% | 0.043 |
| Astra | 5 (586,661) | 0.69 (0.55, 0.82) | 89.00% | 0.001 | |
| Pfizer |
3 (43,131) |
0.67 (0.51, 0.83) | - | - | |
| 2nd Dose Effectiveness | Moderna |
9 (117,034) |
0.93 (0.89, 0.97) | 73.40% | 0.001 |
| Astra |
4 (405,357) |
0.89 (0.80, 0.97) | 89.03% | 0.001 | |
| Pfizer |
4 (43,570) |
0.90 (0.83, 0.96) | 44.32% | 0.049 | |
| 1st Dose Efficacy | Alpha |
1 (108,720) |
0.84 (0.84, 0.84) | - | - |
| Delta |
1 (4360) |
0.46 (0.45, 0.48) | - | - | |
| Non-Beta |
1 (1467) |
0.75 (0.73, 0.78) | - | - | |
| NR | 2 (9862) | 0.83 (0.72, 0.94) | - | ||
| 2nd Dose Efficacy | Alpha | 3 (134,916) | 0.77 (0.57, 0.97) | 99.97% | - |
| Beta | 1 (1467) | 0.10 (0.09, 0.12) | - | - | |
| Non-Alpha | 1 (8534) | 0.77 (0.76, 0.78) | - | - | |
| All Variants | 1 (16,973) | 0.71 (0.70, 0.71) | - | - | |
| Delta | 4 (23,746) | 0.64 (0.58, 0.69) | 97.39% | - | |
| Gamma | 2 (18,866) | 0.68 (0.59, 0.77) | 99.44% | - | |
| NR | 2 (9862) | 0.93 (0.85, 1.00) | 99.51% | - | |
| Other | 4 (52,812) | 0.80 (0.69, 0.91) | 99.91% | - | |
| Undetermined | 1 (9433) | 0.57 (0.56, 0.58) | - | - | |
| 1st Dose Effectiveness | Alpha |
5 (344,072) |
0.74 (0.62, 0.86) | 99.98% | - |
| Beta | 1 (181,304) | 0.61 (0.61, 0.62) | - | - | |
| Delta |
2 (6917) |
0.65 (0.40, 0.89) | 99.71% | - | |
| Gamma | 1 (5186) | 0.74 (0.73, 0.75) | - | - | |
| Other | 4 (20,744) | 0.74 (0.55, 0.93) | 99.92% | - | |
| Unidentified | 1 (5186) | 0.68 (0.66, 0.69) | - | - | |
| Total | 1 (181,304) | 0.82 (0.81, 0.82) | - | - | |
| 2nd Dose Effectiveness | Alpha |
3 (87,222) |
0.86 (0.73–0.98) | 99.97% | - |
| Beta | 1 (181,304) | 0.96 (0.96, 0.96) | - | - | |
| Delta |
3 (7160) |
0.87 (0.82, 0.92) | 95.59% | - | |
| Gamma | 1 (5186) | 0.95 (0.95, 0.96) | - | - | |
| Other | 4 (20,744) | 0.95 (0.92, 0.98) | 99.24% | - | |
| Unidentified | 1 (5186) | 0.80 (0.79, 0.81) | - | - | |
| Total | 1 (181,304) | 0.96 (0.96, 0.96) | - | - | |