Table 1.
ceRNA network mediated by tumor-driven exosomal circRNAs in cancers
Exosomal circRNA | CircBase ID | miRNA | Target gene | Function | Ref. | ||
---|---|---|---|---|---|---|---|
Digestive system malignancy | |||||||
Liver cancer | |||||||
circTMEM45A | hsa_circ_0066659 | miR-665 | IGF2 | Proliferation, metastasis | 18 | ||
circUHRF1 | hsa_circ_0048677 | miR-449c-5p | TIM-3 | Natural killer cell exhaustion, drug resistance | 19 | ||
hsa_circ_0004658 | hsa_circ_0004658 | miR-499b-5p | JAM3 | Proliferation, metastasis | 20 | ||
circ-DB | hsa_circ_0025129 | miR-34a | USP7 | Proliferation, deubiquitination | 21 | ||
circRNA Cdr1 | hsa_circ_0001946 | miR-1270 | AFP | Proliferation, metastasis | 25 | ||
circ-G004213 | hsa-circ-G004213 | miR-513b-5p | PRPF39 | Upregulating drug sensitivity | 26 | ||
circTMEM181 | hsa_circ_0001663 | miR-488-3p | CD39 | Immunosuppression, drug resistance | 27 | ||
circ-0072088 | hsa_circ_103809 | miR-375 | MMP-16 | Metastasis | 28 | ||
circFBLIM1 | hsa_circ_0010090 | miR-338 | LRP6 | Glycolysis, metastasis, apoptosis | 29 | ||
circANTXR1 | hsa_circ_0055033 | miR-532-5p | XRCC5 | Proliferation, metastasis | 31 | ||
circRNA_100284 | hsa_circ_100284 | miR-217 | EZH2 | Proliferation, metastasis | 33 | ||
Colon cancer | |||||||
circ_0006174 | hsa_circ_104852 | miR-1205 | CCND2 | Proliferation, metastasis, drug resistance | 37 | ||
circFNDC3B | hsa_circ_006156 | miR-937-5p | TIMP3 | Metastasis, angiogenesis | 38 | ||
circ-133 | has_circ_0010522 | miR-133a | GEF-H1, RhoA | Proliferation, metastasis | 39 | ||
ciRS-122 | hsa_circ_0005963 | miR-122 | PKM2 | Glycolysis, drug resistance | 41 | ||
circPACRGL | has_circ_0069313 | miR-142-3p | TGF-β1 | Proliferation, metastasis, apoptosis | 42 | ||
miR-506-3p | |||||||
circFMN2 | hsa_circ_0005100 | miR-1182 | hTERT | Proliferation, metastasis | 44 | ||
circ_IFT80 | hsa_circ_0067835 | miR-296-5p | MSI1 | Proliferation, metastasis, apoptosis, drug resistance | 45 | ||
circ-RNF121 | hsa_circ_100876 | miR-1224-5p | FOXM1 | Glycolysis, proliferation, metastasis, apoptosis | 46 | ||
circLONP2 | hsa_circ_0008558 | miR-17 | DGCR8 | Metastasis | 49 | ||
circCOG2 | hsa_circ_101555 | miR-1305 | TGF-β1 | Proliferation, metastasis | 50 | ||
circ_0007334 | hsa_circ_0007334 | miR-577 | KLF12 | Proliferation, metastasis, apoptosis | 53 | ||
Gastric cancer | |||||||
ciRS-133 | hsa_circ_0010522 | miR-133 | PRDM16 | Proliferation, metastasis, adipocyte metabolic | 54 | ||
circNEK9 | hsa_circ_0032683 | miR-409-3p | MAP7 | Proliferation, metastasis | 55 | ||
circ-PVT1 | circ-PVT1 | miR-30a-5p | YAP1 | Proliferation, metastasis, apoptosis, autophagy | 56 | ||
circ-RanGAP1 | hsa_circ_0063526 | miR-877-3p | VEGFA | Proliferation, metastasis | 60 | ||
circ_0000260 | hsa_circ_0000260 | miR-129-5p | MMP11 | Proliferation, metastasis, apoptosis, drug resistance | 61 | ||
circ29 | hsa_circ_0044366 | miR-29a | VEGF | Proliferation, metastasis | 62 | ||
circNHSL1 | hsa_circ_0006835 | miR-149-5p | YWHAZ | Metastasis, glutaminolysis | 63 | ||
Bile duct/gallbladder cancer | |||||||
circ_0020256 | hsa_circ_0020256 | miR-432-5p | E2F3 | Proliferation, metastasis | 64 | ||
Esophagus cancer | |||||||
circ0048117 | hsa-circ-0048117 | miR-140 | TLR4 | M2 macrophage polarization, metastasis | 66 | ||
circ-SFMBT2 | hsa_circ_0000211 | miR-107 | SLC1A5 | Proliferation, metastasis, glutaminolysis | 67 | ||
Pancreatic cancer | |||||||
circZNF91 | hsa-circ-0109315 | miR-23b-3p | SIRT1 | Glycolysis, drug resistance | 68 | ||
circ-PDE8A | hsa_circ_0036627 | miR-338 | MACC1 | Metastasis | 69 | ||
Nervous system malignancy | |||||||
Glioma | |||||||
circMMP1 | hsa_circ_0024108 | miR-433 | HMGB3 | Proliferation, metastasis, apoptosis | 70 | ||
circRNA 0001445 | hsa_circ_0001445 | miR-127-5p | SNX5 | Proliferation, metastasis, apoptosis | 75 | ||
Respiratory neoplasms | |||||||
Lung cancer | |||||||
circSATB2 | hsa_circ_0008928 | miR-326 | FSCN1 | Proliferation, metastasis | 78 | ||
circ_100395 | hsa_circ_100395 | miR-141-3p | LATS2 | Proliferation, metastasis, regulating signaling pathway | 79 | ||
circ_102481 | hsa_circRNA_102481 | miR-30a-5p | ROR1 | Metastasis, apoptosis, drug resistance | 80 | ||
circ_0076305 | hsa_circ_0076305 | miR-186-5p | ABCC1 | Drug resistance | 81 | ||
circFBXW8 | circFBXW8 | miR-370-3p | TRIM44 | Proliferation, metastasis | 82 | ||
circRNA-002178 | has_circ_002178 | miR-34 | PD1/PDL1 | Immunotherapy, diagnosis | 84 | ||
circ_PIP5K1A | hsa_circ_0014130 | miR-101 | ABCC1 | Proliferation, metastasis, apoptosis, drug resistance | 85 | ||
hsa_circ_0002130 | hsa_circ_0002130 | miR-498 | GLUT1/HK2/LDHA | Glycolysis, drug resistance | 86 | ||
circSHKBP1 | hsa_circ_0000936 | miR-1294 | PKM2 | M2 macrophage polarization, proliferation, metastasis | 88 | ||
circUSP7 | hsa_circ_0005152 | miR-934 | SHP2 | Immune infiltration, drug resistance | 90 | ||
Malignant pleural mesothelioma | |||||||
circPLK1 | hsa_circ_0038632 | miR-1294 | HMGA1 | Proliferation, metastasis | 92 | ||
Female malignant tumor | |||||||
Ovarian cancer | |||||||
circWHSC1 | hsa_circ_0001387 | miR-145 | MUC1 | Proliferation, metastasis | 93 | ||
miR-1182 | hTERT | ||||||
circ-0001068 | hsa_circ_0001068 | miR-28-5p | PD1 | Immunotherapy | 95 | ||
circFoxp1 | hsa_circ_0001320 | miR-22 | CEBPG | Proliferation, apoptosis, drug resistance | 97 | ||
miR-150-3p | FMNL3 | ||||||
circPUM1 | circPUM1 | miR-615-5p | NF-kB | Proliferation, metastasis, apoptosis | 98 | ||
miR-6753-5p | MMP2 | ||||||
Breast cancer | |||||||
circHIF1A | hsa_circ_0032138 | miR-580-5p | CD44 | Proliferation | 99 | ||
circPSMA1 | circPSMA1 | miR-637 | Akt1 | Immune infiltration, proliferation, metastasis | 101 | ||
circ-MMP11 | hsa_circ_0062558 | miR-153-3p | ANLN | Proliferation, metastasis, apoptosis, drug resistance | 102 | ||
circ_0001142 | hsa_circ_0001142 | miR-361-3p | PIK3CB | M2 macrophage polarization, proliferation, metastasis | 103 | ||
circCARM1 | hsa_circ_0004552 | miR-1252-5p | PFKFB2 | Glycolysis | 104 | ||
Head and neck malignancy | |||||||
Oral squamous cell carcinoma | |||||||
circGDI2 | hsa_circ_0005379 | miR-424-5p | SCAI | Glycolysis, proliferation, metastasis | 106 | ||
circSPATA6 | hsa_circ_0008202 | miR-182 | TRAF6 | Proliferation, metastasis, apoptosis | 108 | ||
Laryngeal squamous cell carcinoma | |||||||
circRASSF2 | hsa_circ_0059354 | miR-302b-3p | IGF-1R | Proliferation, apoptosis | 111 | ||
Urinary malignancy | |||||||
Bladder carcinoma | |||||||
circPRMT5 | hsa_circ_101320 | miR-30c | SNAIL1 | Metastasis | 119 | ||
Prostate cancer | |||||||
circXIAP | hsa_circ_0005276 | miR-1182 | TPD52 | Proliferation, metastasis, apoptosis, drug resistance | 120 | ||
circRNA HIPK3 | hsa_circ_0000284 | miR-212 | BMI-1 | Proliferation, metastasis, apoptosis | 122 |