Skip to main content
. 2023 May 8;20(6):818–835. doi: 10.7150/ijms.82419

Table 1.

ceRNA network mediated by tumor-driven exosomal circRNAs in cancers

Exosomal circRNA CircBase ID miRNA Target gene Function Ref.
Digestive system malignancy
Liver cancer
circTMEM45A hsa_circ_0066659 miR-665 IGF2 Proliferation, metastasis 18
circUHRF1 hsa_circ_0048677 miR-449c-5p TIM-3 Natural killer cell exhaustion, drug resistance 19
hsa_circ_0004658 hsa_circ_0004658 miR-499b-5p JAM3 Proliferation, metastasis 20
circ-DB hsa_circ_0025129 miR-34a USP7 Proliferation, deubiquitination 21
circRNA Cdr1 hsa_circ_0001946 miR-1270 AFP Proliferation, metastasis 25
circ-G004213 hsa-circ-G004213 miR-513b-5p PRPF39 Upregulating drug sensitivity 26
circTMEM181 hsa_circ_0001663 miR-488-3p CD39 Immunosuppression, drug resistance 27
circ-0072088 hsa_circ_103809 miR-375 MMP-16 Metastasis 28
circFBLIM1 hsa_circ_0010090 miR-338 LRP6 Glycolysis, metastasis, apoptosis 29
circANTXR1 hsa_circ_0055033 miR-532-5p XRCC5 Proliferation, metastasis 31
circRNA_100284 hsa_circ_100284 miR-217 EZH2 Proliferation, metastasis 33
Colon cancer
circ_0006174 hsa_circ_104852 miR-1205 CCND2 Proliferation, metastasis, drug resistance 37
circFNDC3B hsa_circ_006156 miR-937-5p TIMP3 Metastasis, angiogenesis 38
circ-133 has_circ_0010522 miR-133a GEF-H1, RhoA Proliferation, metastasis 39
ciRS-122 hsa_circ_0005963 miR-122 PKM2 Glycolysis, drug resistance 41
circPACRGL has_circ_0069313 miR-142-3p TGF-β1 Proliferation, metastasis, apoptosis 42
miR-506-3p
circFMN2 hsa_circ_0005100 miR-1182 hTERT Proliferation, metastasis 44
circ_IFT80 hsa_circ_0067835 miR-296-5p MSI1 Proliferation, metastasis, apoptosis, drug resistance 45
circ-RNF121 hsa_circ_100876 miR-1224-5p FOXM1 Glycolysis, proliferation, metastasis, apoptosis 46
circLONP2 hsa_circ_0008558 miR-17 DGCR8 Metastasis 49
circCOG2 hsa_circ_101555 miR-1305 TGF-β1 Proliferation, metastasis 50
circ_0007334 hsa_circ_0007334 miR-577 KLF12 Proliferation, metastasis, apoptosis 53
Gastric cancer
ciRS-133 hsa_circ_0010522 miR-133 PRDM16 Proliferation, metastasis, adipocyte metabolic 54
circNEK9 hsa_circ_0032683 miR-409-3p MAP7 Proliferation, metastasis 55
circ-PVT1 circ-PVT1 miR-30a-5p YAP1 Proliferation, metastasis, apoptosis, autophagy 56
circ-RanGAP1 hsa_circ_0063526 miR-877-3p VEGFA Proliferation, metastasis 60
circ_0000260 hsa_circ_0000260 miR-129-5p MMP11 Proliferation, metastasis, apoptosis, drug resistance 61
circ29 hsa_circ_0044366 miR-29a VEGF Proliferation, metastasis 62
circNHSL1 hsa_circ_0006835 miR-149-5p YWHAZ Metastasis, glutaminolysis 63
Bile duct/gallbladder cancer
circ_0020256 hsa_circ_0020256 miR-432-5p E2F3 Proliferation, metastasis 64
Esophagus cancer
circ0048117 hsa-circ-0048117 miR-140 TLR4 M2 macrophage polarization, metastasis 66
circ-SFMBT2 hsa_circ_0000211 miR-107 SLC1A5 Proliferation, metastasis, glutaminolysis 67
Pancreatic cancer
circZNF91 hsa-circ-0109315 miR-23b-3p SIRT1 Glycolysis, drug resistance 68
circ-PDE8A hsa_circ_0036627 miR-338 MACC1 Metastasis 69
Nervous system malignancy
Glioma
circMMP1 hsa_circ_0024108 miR-433 HMGB3 Proliferation, metastasis, apoptosis 70
circRNA 0001445 hsa_circ_0001445 miR-127-5p SNX5 Proliferation, metastasis, apoptosis 75
Respiratory neoplasms
Lung cancer
circSATB2 hsa_circ_0008928 miR-326 FSCN1 Proliferation, metastasis 78
circ_100395 hsa_circ_100395 miR-141-3p LATS2 Proliferation, metastasis, regulating signaling pathway 79
circ_102481 hsa_circRNA_102481 miR-30a-5p ROR1 Metastasis, apoptosis, drug resistance 80
circ_0076305 hsa_circ_0076305 miR-186-5p ABCC1 Drug resistance 81
circFBXW8 circFBXW8 miR-370-3p TRIM44 Proliferation, metastasis 82
circRNA-002178 has_circ_002178 miR-34 PD1/PDL1 Immunotherapy, diagnosis 84
circ_PIP5K1A hsa_circ_0014130 miR-101 ABCC1 Proliferation, metastasis, apoptosis, drug resistance 85
hsa_circ_0002130 hsa_circ_0002130 miR-498 GLUT1/HK2/LDHA Glycolysis, drug resistance 86
circSHKBP1 hsa_circ_0000936 miR-1294 PKM2 M2 macrophage polarization, proliferation, metastasis 88
circUSP7 hsa_circ_0005152 miR-934 SHP2 Immune infiltration, drug resistance 90
Malignant pleural mesothelioma
circPLK1 hsa_circ_0038632 miR-1294 HMGA1 Proliferation, metastasis 92
Female malignant tumor
Ovarian cancer
circWHSC1 hsa_circ_0001387 miR-145 MUC1 Proliferation, metastasis 93
miR-1182 hTERT
circ-0001068 hsa_circ_0001068 miR-28-5p PD1 Immunotherapy 95
circFoxp1 hsa_circ_0001320 miR-22 CEBPG Proliferation, apoptosis, drug resistance 97
miR-150-3p FMNL3
circPUM1 circPUM1 miR-615-5p NF-kB Proliferation, metastasis, apoptosis 98
miR-6753-5p MMP2
Breast cancer
circHIF1A hsa_circ_0032138 miR-580-5p CD44 Proliferation 99
circPSMA1 circPSMA1 miR-637 Akt1 Immune infiltration, proliferation, metastasis 101
circ-MMP11 hsa_circ_0062558 miR-153-3p ANLN Proliferation, metastasis, apoptosis, drug resistance 102
circ_0001142 hsa_circ_0001142 miR-361-3p PIK3CB M2 macrophage polarization, proliferation, metastasis 103
circCARM1 hsa_circ_0004552 miR-1252-5p PFKFB2 Glycolysis 104
Head and neck malignancy
Oral squamous cell carcinoma
circGDI2 hsa_circ_0005379 miR-424-5p SCAI Glycolysis, proliferation, metastasis 106
circSPATA6 hsa_circ_0008202 miR-182 TRAF6 Proliferation, metastasis, apoptosis 108
Laryngeal squamous cell carcinoma
circRASSF2 hsa_circ_0059354 miR-302b-3p IGF-1R Proliferation, apoptosis 111
Urinary malignancy
Bladder carcinoma
circPRMT5 hsa_circ_101320 miR-30c SNAIL1 Metastasis 119
Prostate cancer
circXIAP hsa_circ_0005276 miR-1182 TPD52 Proliferation, metastasis, apoptosis, drug resistance 120
circRNA HIPK3 hsa_circ_0000284 miR-212 BMI-1 Proliferation, metastasis, apoptosis 122