Table 2.

Tumor-driven exosomal circRNAs and clinical applications

Clinical objective		Tumor-driven exosomal circRNAs
Diagnosis	Cancer diagnosis and early cancer screening	circLPAR1, circ-PNN, circ_0055202, circ_0074920, circ_0043722, circRNA-002178, circKIAA1244, circ_0004001, circ_0004123, circ_0075792, circ_0065149, circ-0004771, circ_0003828, circ_0075828, circ_0002976, circ_0069313
	Predict cancer recurrence and metastasis	circ_30029, circ_117300, circ_176436, circ_112897, circ_112897, circ_178252, circ_115617, circ_14736, circ_17720, circ_0000199, circMYC, circ_0005019, circ_0000880, circ_0051680, circ_0006365, circ_0056616, circ_0019201, circ_0011773, circ_0122790, circ_0006602
	Predicting treatment sensitivity	circMYC
Treatment	Promote chemotherapy resistance	circ_0058493, circ_0006174, circUHRF1, circZNF91, circ_102481, circRNA-SORE, ciRS-122, circ_0042003, circ_PIP5K1A, circ_103801, circ_0002130, circFoxp1, circMYC, circTMEM181, circ_0000338, circUSP7
	Promote radiation resistance	circCUX1, circMYC, circ_IFT80
	Increasing chemotherapy sensitivity	Cdr1, circ_G004213