Table 1. Baseline and clinical characteristics of the study population.
Patients characteristics | Survivors (n = 123) | Non-survivors (n = 63) | P |
---|---|---|---|
Male, n (%) | 76 | 44 | 0.277 |
Age, mean ± SD | 72.38 ± 9.64 | 74.57 ± 8.57 | 0.199 |
Infection sites leading to ICU admission, n(%) | 0.761 | ||
Respiratory infection | 55 (44.72%) | 27 (42.85%) | |
Urinary tract infection | 27 (21.95%) | 16 (25.40%) | |
Bloodstream infections | 11 (8.94%) | 3 (4.76%) | |
Abdominal cavity infection | 24 (19.51%) | 15 (23.81%) | |
Others | 6 (4.88%) | 2 (3.17%) | |
Past medical history, n (%) | 0.877 | ||
Coronary heart disease | 65 (85.53%) | 47 (74.60%) | |
Hypertension | 42 (55.26%) | 26 (41.27%) | |
Diabetes mellitus | 32 (42.11%) | 18 (28.57%) | |
Cerebrovascular disease | 19 (25%) | 14 (22.22%) | |
APACHE II score, mean ± SD | 24.03 ± 5.90 | 30.28 ± 6.67 | 0.000 |
SOFA score, mean ± SD | 8.67 ± 3.12 | 12.14 ± 3.00 | 0.000 |
Vital signs on ICU admission | |||
SBP, mmHg, median (IQR) | 82.00 (78.00, 87.00) | 85.00 (79.00, 90.00) | 0.146 |
DBP, mmHg, median (IQR) | 50.00 (48.00, 60.00) | 50.00 (45.00, 60.00) | 0.273 |
MAP, mmHg, median (IQR) | 61.67 (57.33. 68.33) | 61.67 (56.67, 70.00) | 0.915 |
Pulse rate, beats/min,, median (IQR) | 123.00 (104.00, 139.00) | 147.00 (105.00, 153.00) | 0.020 |
Body temperature, °C, mean ± SD | 38.42 ± 0.71 | 38.59 ± 0.71 | 0.137 |
Respiratory rate, breaths/min, mean ± SD | 33.87 ± 9.77 | 35.02 ± 11.43 | 0.476 |
Laboratory indicators | |||
WBC, ×109/L, mean ± SD | 16.32 ± 8.18 | 14.40 ± 7.17 | 0.116 |
PCT, ng/mL, median (IQR) | 16.27 (5.31, 35.10) | 16.87 (5.52, 35.29) | 0.368 |
IL-6, pg/mL, median (IQR) | 84.27 (27.38, 243.00) | 129.91 (26.31, 1015,24) | 0.086 |
Platelet, ×109 /L, median (IQR) | 90.00 (65.00, 190.00) | 140.00 (57.00, 210.00) | 0.390 |
Albumin, g/L, median (IQR) | 30.00 (27.00, 43.00) | 31.00 (27.00, 40.00) | 0.539 |
Creatinine, μmol/L, mean ± SD | 248.20 ± 123.59 | 299.38 ± 125.19 | 0.008 |
PaO2/FiO2, mmHg, median (IQR) | 217.54 (198.63, 267.32) | 165.43 (98.63, 200.39) | 0.000 |
Lactate, mmol/L, median (IQR) | 11.40 (8.80, 12.60) | 11.40 (9.40, 12.80) | 0.653 |
Notes.
- APACHE II score
- acute physiology and chronic health evaluation II score
- ICU
- intensive care unit
- WBC
- White blood cell
- PCT
- Procalcitonin
- SBP
- Systolic blood pressure
- DBP
- Diastolic blood pressure
- MAP
- Mean arterial pressure
- SOFA score
- Sequential Organ Failure Assessment score
- IL-6
- interleukin-6