Table 1b.
PACK-CXL Protocol Details: Fluorescent Imaging Assay
| Chromophore | ||||||||
|---|---|---|---|---|---|---|---|---|
| Treatment Group | Fluence [J/cm2] | Intensity [mW/cm2] | Total Irradiation Time [min] | Type | Concentration | Carrier | Replenishment | Sample Size |
| Control epi-on | – | – | – | – | – | – | – | 25 |
| Control epi-off | – | – | – | – | – | – | – | 86 |
| Fluence 5.4 J/cm2 | 5.4 | 9 | 10 | Riboflavin | 0.1% | Dextran | yes | 33 |
| Fluence 5.4 J/cm2; 0.4.% riboflavin | 5.4 | 9 | 10 | Riboflavin* | 0.4% | Dextran | yes | 14 |
| Fluence 5.4 J/cm2; HPMC | 5.4 | 9 | 10 | Riboflavin | 0.1% | HPMC | yes | 12 |
| Fluence 16.2 J/cm2 | 16.2 | 9 + 2 × 45 | 14 | Riboflavin | 0.1% | Dextran | yes | 14 |
| Fluence 16.2 J/cm2; no riboflavin replenishment | 16.2 | 9 + 2 × 45 | 14 | Riboflavin | 0.1% | Dextran | no | 12 |
Epi-on: corneal epithelium intact; Epi-off: corneal epithelium removed; * Commercial product not available, prepared by pharmacist.