Table III.
Predictive factors for long-term complications
| All patients (N = 77) | No complications (N = 41) | Complications (N = 36) | Univariate | Multivariate† | |||
|---|---|---|---|---|---|---|---|
| P | OR (95% CI) | P | OR (95% CI) | ||||
| Gender, no. (%) | |||||||
| Female | 33(43) | 16(44) | 17(42) | ||||
| Male | 44(57) | 20(56) | 24(59) | 0.792 | 0.89 (0.36-2.19) | ||
| Median age, years (range) | 65 (22-96) | 67 (22-93) | 65 (26-96) | 0.573 | 0.99 (0.96-1.02) | ||
| Smoker, no. (%) | |||||||
| No | 49(64) | 26(72) | 23(56) | ||||
| Yes | 28(36) | 10(28) | 18(44) | 0.145 | 2.04 (0.78-5.29) | 0.128 | 2.71 (0.75-9.83) |
| CCI, no. (%) | |||||||
| ≤ 2 | 32(42) | 13(36) | 19(46) | ||||
| > 2 | 45(58) | 23(64) | 22(54) | 0.364 | 0.65 (0.26-1.64) | ||
| Stage, no. (%) | |||||||
| 1-2 | 29(38) | 18(50) | 11(27) | ||||
| 3-4 | 48(62) | 18(50) | 30(73) | 0.039* | 2.73 (1.05-7.06) | 0.661 | 1.31 (0.39-4.34) |
| Management, no. (%) | |||||||
| Surgery alone | 17(22) | 15(42) | 2(5) | ||||
| Adjuvant or definitive RT/CRT | 60(78) | 21(58) | 39(95) | 0.001* | 13.93 (2.90-66.81) | 0.001* | 18.86 (3.31-107.6) |
| Surgery type, no. (%) | |||||||
| Open | 32(50) | 14(47) | 18(53) | ||||
| Endoscopic | 27(42) | 13(43) | 14(41) | 0.736 | 0.84 (0.30-2.34) | ||
| Combined | 5(8) | 3(10) | 2(6) | 0.503 | 0.52 (0.76-3.54) | ||
| RT/CRT, no. (%) | |||||||
| RT | 40(67) | 15(71) | 25(64) | ||||
| CRT | 20(33) | 6(29) | 14(36) | 0.567 | 1.40 (0.44-4.43) | ||
| Radiation modality, no. (%) | |||||||
| External beam radiation | 23(38) | 11(52) | 12(31) | ||||
| IMRT | 37(62) | 10(48) | 27(69) | 0.104 | 2.48 (0.83-7.38) | 0.135 | 2.36 (0.77-7.29) |
| Radiation dose, no. (%) | |||||||
| < 60 Gy | 12(25) | 5(33) | 7(21) | ||||
| ≥ 60 Gy | 36(75) | 10(67) | 26(79) | 0.372 | 1.86 (0.48-7.23) | ||
| CCI: Charlson comorbidity index; RT: radiotherapy; CRT: chemoradiotherapy; IMRT: intensity-modulated radiation therapy; Gy: Gray; OR: odds ratio; CI: confidence interval; * Statistically significant. † Variables with a two-sided p-value < 0.2 from univariate analysis were included in a multivariate analysis. | |||||||