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. 2023 May 17;43(20):3764–3785. doi: 10.1523/JNEUROSCI.2102-22.2023

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Copyright © 2023 Walker et al.

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Figure 8. — Relative protein abundance of TWF2 positively correlates with spine length. A, Module 16 eigenprotein abundance exhibits a significant positive correlation with dendritic spine length. B, Module 16 eigenprotein abundance is significantly positively correlated with thin spine length. Each point represents one case. N = 45 (17 Control, 6 CAD, 22 AD). C, Gene ontology (GO) for Module 16 indicates involvement in protein folding. Module 16 eigenprotein abundance does not differ among control, CAD, and AD synaptosomes. N = 57 (19 Control, 7 CAD, 31 AD). Error bars indicate the 25th and 75th percentiles. D, The top 6 hub proteins for Module 16 are shown. TWF2 is the top hub protein. E, Log₂-transformed relative protein abundance of TWF2 positively correlates with spine length. F, Log₂-transformed relative protein abundance of TWF2 was plotted against thin spine length. For E, F, points represent individual cases and the best fit line was determined via linear model. For A, B, E, F, correlations were assessed by biweight midcorrelation (bicor).