Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 16;10(5):ENEURO.0429-22.2023. doi: 10.1523/ENEURO.0429-22.2023

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Sharma et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Figure 7. — Tonic stimulation (50 Hz) evoked ECAP and ESAP (S1). A, Evoked responses from the tonic stimulation of epidural spinal cord at 300 μA (40-μs pulse width, 250 stimulation events) Trigger is shown at the top. The black lines at top correspond to early (i), middle (ii), and late (iii) events shown at the bottom. The ESAP (S1) is distinctly recognizable in (i), attenuates in (ii) and (iii). B, Representative traces of the evoked response comprising of ECAP and ESAP (S1) from event 1 (blue), averaged responses from event 20 to event 30 (red), and those from event 240–250 (purple) show a gradual decrease in the ESAP (S1) amplitude with increasing events. C, Comparison of the ESAP (S1) amplitude (pink) between events. Moving average of four events is computed to smoothen the data for the amplitude of ESAP (S1) from event 7 and the amplitude of ECAP (P2-N1, brown) from event 4 onwards. Rest of the data are represented in absolute values. The ESAP (S1) amplitude drops while the ECAP amplitude stays consistent except for the first three events. D, Latencies for N1, P2, N2, and S1, plotted as a function of event. Moving average of four events is computed to smoothen the data for the latencies of ESAP (S1, pink) and ECAP (N1, brown; P2, black, N2, green) from event 4 onwards. ECAP- Evoked Compound Action Potential; ESAP - Evoked Synaptic Activity Potential; P1, N1, P2 - ECAP waveforms; S1- ESAP waveform.Figure Contributions: Mahima Sharma performed the experiments and analyzed the data.