Skip to main content
. 2023 May 16;10(5):ENEURO.0429-22.2023. doi: 10.1523/ENEURO.0429-22.2023

Figure 8.

Figure 8.

Sensitivity of ESAP (S1) and ECAP to 1 Hz versus Tonic (at 50 Hz) SCS. A, Comparison of the evoked ESAP (S1) responses from 1-Hz stimulation events (blue, Fig. 1A) versus 50-Hz SCS events (orange). Evoked ESAP responses at different stimulation events (1–20) are reported as the percentage of the ESAP value at the first event. B, Comparison of the evoked ECAP responses from 1-Hz stimulation (blue) versus 50-Hz stimulation (orange). Evoked ECAP values at different stimulation events (1–20) are reported as the percentage of the ECAP value at the first event. C, Latencies for evoked ECAP and ESAP: N1 (brown), P2 (black), N2 (green), and S1 (pink) for 1-Hz stimulation (n = 5). D, Latencies for evoked ECAP and ESAP: N1 (brown), P2 (black), N2 (green), and S1 (pink) for 50-Hz stimulation. Data represented as mean ± SEM (n = 5). Statistical power using Bonferroni post hoc test comparing percent change in amplitudes at event 1 with those at rest of the events assumed at *p < 0.05, **p < 0.01, ***p < 0.001. ECAP- Evoked Compound Action Potential; ESAP - Evoked Synaptic Activity Potential; P1, N1, P2 - ECAP waveforms; S1- ESAP waveform.Figure Contributions: Mahima Sharma performed the experiments and analyzed the data.