Table 1.
Summary of statistical analysis used to characterize the Evoked Synaptic Activity Potential (ESAP)
| Figure | Measurement | Comparison | N | Statistical test | Results |
|---|---|---|---|---|---|
| S1 (ESAP) amplitude | Control vs CNQX | 14 | Wilcoxon signed-rank test | p = 0.0001 | |
| ECAP amplitude | Control vs CNQX | 14 | Wilcoxon signed-rank test | p = 0.0562 | |
| Spinal stimulation evoked S1 (ESAP) latency |
Intraspinal vs epidural response | 10 | Paired sample t test | t(9) = 1.35, p = 0.38 | |
| Motor cortical stimulation evoked S1 (ESAP) latency |
Intraspinal vs epidural response | 10 | Paired sample t test | t(9) = 1.73, p = 0.15 | |
| Current thresholds | S1 vs EMG | 9 | Paired sample t test | t(8) = 6.04, p < 0.0001 | |
| Latencies | S1 vs EMG | 9 | Paired sample t test | t(8) = 15.7, p < 0.0001 | |
| 7A | S1 (ESAP) amplitude during 50-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 6.5162, p = 8.4244e-10 |
| 7A | S1 (ESAP) amplitude during 1-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 1.3284, p = 0.1898 |
| 7B | ECAP amplitude during 50-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 1.2822, p = 0.2188 |
| 7B | ECAP amplitude during 1-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 0.3226, p = 0.9964 |
| 7D | S1 (ESAP) latency during 50-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 0.75, p = 0.7579 |
| 7C | S1 (ESAP) latency during 1-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 0.23, p = 0.9996 |
| 7D | ECAP (N1) latency during 50-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 0.02, p = 1 |
| 7C | ECAP (N1) latency during 1-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 1.73, p = 0.049 |
| 7D | ECAP (P2) latency during 50-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 0.06, p = 1 |
| 7C | ECAP (P2) latency during 1-Hz SCS | Increasing stimulation pulse count (1–20) | 5 | One-way ANOVA | F(19,80) = 0.95, p = 0.5225 |