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. 2023 May 5;12:e85714. doi: 10.7554/eLife.85714

Figure 2. Type 2 diabetes (T2D) causes low turnover osteopenia.

(A) Bone mineral density (BMD) for the whole body (minus head) and one leg (femur and tibia). CTRL, n=6; T2D, n=9. (B) Representative µCT images. (C) Quantitative analysis of trabecular bone of the distal femur. n=6. (D) Quantitative analysis of cortical bone in femur. CTRL, n=6; T2D, n=7. (E) Serum bone formation (P1NP) and resorption (CTX-1) markers. CTRL, n=6; T2D, n=9. (F, G) Representative images (F) and quantification (G) for double labeling of trabecular bone in the distal femur. n=5. Data are mean ± SD. Unpaired Student’s t-tests. *p<0.05.

Figure 2.

Figure 2—figure supplement 1. Diabetic osteopenia in Type 2 diabetes (T2D) mouse model.

Figure 2—figure supplement 1.

(A) Body length (cm) from nose tip to the anus. n=4. (B) Femur length measured by DEXA. CTRL, n=6; T2D, n=9. (C–F) Trabecular bone parameters by µCT. n=6. (G, H) Cortical bone parameters by µCT. CTRL, n=6; T2D, n=7. (I, J) Double labeling analysis of periosteum. n=6. (K, L) Double labeling analysis of endosteum. n=6. Data are represented as mean ± SD. *p<0.05, Student’s t-test.