Fig. 2.

Sepsis is a heterogenous clinical syndrome caused by multiple pathogens including bacteria and viruses that induce a host response. (A) This host response causes alterations in the MK and platelet transcriptome. The platelet transcriptome results in altered platelet activation, including alterations in sub-populations of septic patients (B). Platelet aggregation in response to agonists (C) in sepsis suggests altered function of specific receptors in sepsis.