Table 2.
Circumpapillary RNFL sector thickness (Garway-Heath-based grid) and macular thickness of the GCC layers and INL (ETDRS grid subfields)
| Parameters | CG (N=25) | GON (N=25) | CON (N=25) | CG x GON Adj. p-value |
CG x CON Adj. p-value |
GON x CON Adj. p-value |
|||
|---|---|---|---|---|---|---|---|---|---|
| cpRNFL | |||||||||
| G | 99.00 | (9.20) | 63.72 | (15.28) | 61.92 | (16.82) | <0.001 | <0.001 | 1.000 |
| NS | 117.40 | (20.44) | 75.52 | (21.13) | 71.96 | (28.30) | <0.001 | <0.001 | 0.530 |
| N | 83.64 | (11.26) | 55.96 | (15.48) | 50.00 | (18.68) | <0.001 | <0.001 | 1.000 |
| NI | 125.16 | (26.79) | 74.00 | (26.77) | 70.88 | (30.01) | <0.001 | <0.001 | 1.000 |
| TI | 148.12 | (18.83) | 85.92 | (36.97) | 99.28 | (34.49) | <0.001 | <0.001 | 0.401 |
| T | 65.52 | (11.11) | 47.68 | (12.46) | 41.76 | (13.24) | <0.001 | <0.001 | 0.280 |
| TS | 124.44 | (25.24) | 76.28 | (29.21) | 84.20 | (29.68) | <0.001 | <0.001 | 0.968 |
| mRNFL | |||||||||
| C | 12.76 | (2.45) | 10.84 | (3.00) | 9.76 | (2.35) | 0.034 | <0.001 | 0.446 |
| IS | 24.24 | (2.88) | 20.24 | (2.88) | 18.44 | (2.53) | <0.001 | <0.001 | 0.073 |
| OS* | 36.00 | (3.00) | 28.00 | (14.00) | 25.00 | (9.00) | <0.001 | <0.001 | 1.000 |
| IN* | 21.00 | (3.00) | 19.00 | (4.00) | 17.00 | (4.00) | 0.067 | <0.001 | 0.012 |
| ON | 46.12 | (6.15) | 32.28 | (8.11) | 27.16 | (7.06) | <0.001 | <0.001 | 0.041 |
| II* | 25.00 | (3.00) | 21.00 | (6.00) | 18.00 | (3.00) | <0.001 | <0.001 | 0.415 |
| OI | 39.44 | (5.96) | 24.60 | (6.93) | 26.76 | (6.89) | <0.001 | <0.001 | 0.755 |
| IT* | 17.00 | (1.00) | 18.00 | (2.00) | 18.00 | (4.00) | 1.000 | 0.368 | 1.000 |
| OT | 19.08 | (1.68) | 18.44 | (2.18) | 17.36 | (1.98) | 0.754 | 0.008 | 0.165 |
| mGCL | |||||||||
| C* | 14.00 | (7.00) | 12.00 | (4.00) | 9.00 | (3.00) | 0.026 | <0.001 | 0.090 |
| IS | 51.36 | (5.31) | 38.12 | (11.29) | 32.72 | (9.00) | <0.001 | <0.001 | 0.105 |
| OS | 34.88 | (3.27) | 28.00 | (5.45) | 26.64 | (5.38) | <0.001 | <0.001 | 0.961 |
| IN* | 50.00 | (7.00) | 40.00 | (18.00) | 23.00 | (15.00) | <0.001 | <0.001 | 0.013 |
| ON* | 39.00 | (7.00) | 33.00 | (10.00) | 26.00 | (8.00) | 0.003 | <0.001 | 0.074 |
| II | 51.64 | (5.41) | 36.20 | (10.43) | 33.28 | (10.30) | <0.001 | <0.001 | 0.768 |
| OI* | 33.00 | (7.00) | 25.00 | (7.00) | 26.00 | (8.00) | <0.001 | <0.001 | 1.000 |
| IT | 48.24 | (5.30) | 31.48 | (9.82) | 30.76 | (9.50) | <0.001 | <0.001 | 1.000 |
| OT | 35.16 | (3.18) | 24.76 | (5.11) | 25.52 | (6.77) | <0.001 | <0.001 | 1.000 |
| IPL | |||||||||
| C* | 20.00 | (5.00) | 18.00 | (5.00) | 16.00 | (3.00) | 0.034 | <0.001 | 0.151 |
| IS* | 40.00 | (6.00) | 37.00 | (10.00) | 29.00 | (7.00) | 0.002 | <0.001 | 0.043 |
| OS | 28.64 | (2.56) | 24.96 | (3.39) | 23.40 | (2.89) | <0.001 | <0.001 | 0.201 |
| IN* | 42.00 | (6.00) | 37.00 | (11.00) | 26.00 | (9.00) | 0.007 | <0.001 | 0.002 |
| ON* | 30.00 | (5.00) | 27.00 | (7.00) | 22.00 | (7.00) | 0.04 | <0.001 | 0.015 |
| II | 40.80 | (3.25) | 32.68 | (6.47) | 29.80 | (5.58) | <0.001 | <0.001 | 0.173 |
| OI | 27.12 | (2.35) | 23.40 | (3.79) | 22.76 | (2.80) | <0.001 | <0.001 | 1.000 |
| IT | 42.08 | (2.89) | 32.92 | (6.16) | 31.16 | (6.30) | <0.001 | <0.001 | 0.746 |
| OT | 32.32 | (2.45) | 27.20 | (3.18) | 26.56 | (4.14) | <0.001 | <0.001 | 1.000 |
| INL | |||||||||
| C* | 22.00 | (10.00) | 20.00 | (8.00) | 18.00 | (8.00) | 1.000 | 0.260 | 0.469 |
| IS | 42.80 | (4.04) | 45.04 | (5.80) | 45.32 | (6.87) | 0.505 | 0.365 | 1.000 |
| OS | 32.40 | (2.20) | 34.12 | (3.18) | 33.32 | (4.15) | 0.202 | 0.972 | 1.000 |
| IN* | 42.00 | (5.00) | 45.00 | (6.00) | 43.00 | (7.00) | 0.177 | 0.852 | 1.000 |
| ON | 34.68 | (2.67) | 36.68 | (3.81) | 36.48 | (4.82) | 0.215 | 0.313 | 1.000 |
| II* | 41.00 | (5.00) | 45.00 | (9.00) | 43.00 | (9.00) | 0.040 | 1.000 | 0.378 |
| OI* | 32.00 | (3.00) | 34.00 | (4.00) | 33.00 | (5.00) | 0.005 | 0.285 | 0.438 |
| IT | 39.68 | (3.42) | 41.12 | (5.97) | 39.12 | (4.39) | 0.851 | 1.000 | 0.413 |
| OT* | 33.00 | (2.00) | 35.00 | (4.00) | 34.00 | (5.00) | 0.023 | 1.000 | 0.165 |
Measurements are presented in μm and are described as mean ± standard deviation or median and interquartile range. Adj, adjusted; CG, healthy control group; CON, compressive optic neuropathy; cpRNFL, circumpapillary retinal nerve fiber layer; ETDRS, Early Treatment of Diabetic Retinopathy Study; GCC, ganglion cell complex; GON, glaucomatous optic neuropathy; IPL, inner plexiform layer; INL, inner nuclear layer; mGCL, macular ganglion cell layer; mRNFL, macular retinal nerve fiber layer; Garway-Heath-based sectors: G, Global; N, nasal; NI, nasal-inferior; NS, nasal-superior; T, temporal; TI, temporal-inferior; TS, temporal-superior. ETDRS subfields: C, central; II, inner inferior; IN, inner nasal; IS, inner superior; IT, inner temporal; OI, outer inferior; ON, outer nasal; OS, outer superior; OT, outer temporal
*Values presented in median and interquartile range
Significant p-values are in bold