Table 3.
Macular GCC layer sector thickness according to Garway-Heath-based grid
| Parameters | CG (N=25) |
GON (N=25) |
CON (N=25) |
CG x GON Adj. p-value |
CG x CON Adj. p-value |
GON x CON Adj. p-value |
CON x GON | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | 95% CI | Adj. p-value | ||||||||||
| mRNFL | ||||||||||||
| G | 23.82 | (3.02) | 20.24 | (1.94) | 18.64 | (1.78) | <0.001 | <0.001 | 0.046 | 0.734 | 0.596–0.873 | 0.004 |
| S* | 26.00 | (3.00) | 21.00 | (5.00) | 19.00 | (4.00) | <0.001 | <0.001 | 0.404 | 0.640 | 0.484–0.796 | 0.090 |
| I* | 28.00 | (4.00) | 22.00 | (8.00) | 20.00 | (4.00) | <0.001 | <0.001 | 1.000 | 0.568 | 0.401–0.735 | 0.410 |
| NS | 26.59 | (3.92) | 21.60 | (3.15) | 19.12 | (2.74) | <0.001 | <0.001 | 0.028 | 0.710 | 0.567–0.853 | 0.011 |
| NI* | 25.00 | (4.00) | 21.00 | (5.00) | 18.00 | (2.00) | 0.002 | <0.001 | 0.112 | 0.698 | 0.548–0.848 | 0.017 |
| TS* | 18.00 | (1.00) | 18.00 | (3.00) | 18.00 | (3.00) | 0.670 | 1.000 | 0.560 | 0.608 | 0.451–0.765 | 0.190 |
| TI* | 21.00 | (4.00) | 19.00 | (2.00) | 18.00 | (2.00) | 0.003 | <0.001 | 1.000 | 0.586 | 0.428–0.745 | 0.295 |
| NS/TI | 1.26 | (0.13) | 1.18 | (0.24) | 1.08 | (0.16) | 0.468 | 0.003 | 0.127 | 0.632 | 0.476–0.788 | 0.109 |
| NI/TI | 1.16 | (0.09) | 1.12 | (0.18) | 1.04 | (0.13) | 0.768 | 0.008 | 0.131 | 0.683 | 0.532–0.834 | 0.026 |
| mGCL | ||||||||||||
| G | 50.27 | (4.85) | 36.12 | (8.44) | 31.08 | (7.99) | <0.001 | <0.001 | 0.054 | 0.685 | 0.535–0.834 | 0.025 |
| S | 51.14 | (5.21) | 37.64 | (11.16) | 33.04 | (8.27) | <0.001 | <0.001 | 0.196 | 0.622 | 0.462–0.783 | 0.138 |
| I | 51.05 | (5.26) | 36.04 | (9.50) | 31.92 | (8.64) | <0.001 | <0.001 | 0.231 | 0.636 | 0.479–0.793 | 0.099 |
| NS | 50.91 | (5.30) | 40.08 | (10.76) | 29.56 | (8.58) | <0.001 | <0.001 | <0.001 | 0.772 | 0.640–0.904 | 0.001 |
| NI | 51.18 | (5.11) | 38.72 | (9.25) | 28.00 | (8.97) | <0.001 | <0.001 | <0.001 | 0.793 | 0.668–0.917 | <0.001 |
| TS | 47.68 | (5.08) | 32.08 | (10.42) | 29.84 | (8.30) | <0.001 | <0.001 | 1.000 | 0.554 | 0.390–0.717 | 0.516 |
| TI | 50.23 | (5.15) | 32.56 | (11.35) | 34.08 | (10.36) | <0.001 | <0.001 | 1.000 | 0.466 | 0.303–0.628 | 0.677 |
| NS/TI* | 1.02 | (0.06) | 1.13 | (0.65) | 0.88 | (0.35) | 0.685 | 0.103 | 0.002 | 0.759 | 0.627–0.891 | 0.002 |
| NI/TI* | 1.02 | (0.06) | 1.13 | (0.54) | 0.86 | (0.36) | 0.563 | 0.011 | <0.001 | 0.823 | 0.709–0.937 | <0.001 |
| NI + NI/TI | 0.860 | 0.759–0.961 | <0.001 | |||||||||
| IPL | ||||||||||||
| G | 41.14 | (3.17) | 33.48 | (5.03) | 29.04 | (4.76) | <0.001 | <0.001 | 0.002 | 0.736 | 0.596–0.876 | 0.004 |
| S | 40.68 | (3.76) | 33.64 | (6.36) | 29.28 | (4.11) | <0.001 | <0.001 | 0.008 | 0.711 | 0.563–0.860 | 0.010 |
| I* | 39.00 | (5.00) | 34.00 | (10.00) | 28.00 | (7.00) | <0.001 | <0.001 | 0.191 | 0.685 | 0.530–0.839 | 0.025 |
| NS* | 41.50 | (7.00) | 37.00 | (12.00) | 27.00 | (7.00) | 0.018 | <0.001 | 0.002 | 0.802 | 0.680–0.923 | <0.001 |
| NI* | 42.00 | (6.00) | 36.00 | (10.00) | 25.00 | (8.00) | 0.003 | <0.001 | 0.002 | 0.843 | 0.733–0.954 | <0.001 |
| TS | 41.32 | (3.12) | 32.64 | (6.75) | 30.52 | (5.90) | <0.001 | <0.001 | 0.547 | 0.595 | 0.435–0.755 | 0.248 |
| TI | 40.86 | (2.42) | 32.00 | (6.90) | 31.56 | (6.14) | <0.001 | <0.001 | 1.000 | 0.526 | 0.364–0.689 | 0.749 |
| NS/TI* | 1.00 | (0.08) | 0.98 | (0.34) | 0.95 | (0.33) | 1.000 | 0.162 | 0.087 | 0.675 | 0.525–0.825 | 0.034 |
| NI/TI* | 1.02 | (0.06) | 1.06 | (0.22) | 0.92 | (0.32) | 1.000 | 0.004 | <0.001 | 0.819 | 0.705–0.933 | <0.001 |
| NI + NI/TI | 0.874 | 0.777–0.972 | <0.001 | |||||||||
| IPL + GCL | ||||||||||||
| NI + NI/TI | 0.909 | 0.830–0.988 | <0.001 | |||||||||
Measurements are presented in μm and are described as mean ± standard deviation or median and interquartile range. Adj, adjusted; AUC, area under the curve; CON, compressive optic neuropathy; CI, confidence interval; CG, healthy control group; GCC, ganglion cell complex; G, global; I, inferior; IPL, inner plexiform layer; mGCL, macular ganglion cell layer; mRNFL, macular retinal nerve fiber layer; NI, nasal-inferior. NI/TI, nasal-inferior/temporal-inferior ratio; NS, nasal-superior; NS/TI, nasal-superior/temporal-inferior ratio; S, superior; TI, temporal-inferior; TS, temporal-superior
*Values presented in median and interquartile range
Significant p-values are in bold