Skip to main content
. Author manuscript; available in PMC: 2024 May 17.
Published in final edited form as: Neuron. 2023 Apr 6;111(10):1531–1546. doi: 10.1016/j.neuron.2023.03.021

Figure 3. Factors influencing heterogeneity of cognitive outcomes in the Lewy body diseases.

Figure 3.

Inherent pathologic features of “proteinopathy” (as exemplified by aSyn strain, or amount of co-existing AD pathology) are modulated by individual host features (genetic background and environmental exposures throughout life), resulting in varying cognitive presentations. PD-NC = Parkinson’s disease with normal cognition, PD-MCI = Parkinson’s disease with mild cognitive impairment, PDD = Parkinson’s disease with dementia, DLB = dementia with Lewy bodies.