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. 2022 Dec 23;72(6):1603–1618. doi: 10.1007/s00262-022-03346-7

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© The Author(s) 2022

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Fig. 6 — Heterogeneity of Granzyme B loss in ccRCC. Representative examples of tumors with loss of Granzyme B (patient 4) or maintained Granzyme B expression (patient 11). Scale bar = 250 μm (A). Semiquantitative assessment of Granzyme B + tumor-infiltrating lymphocytes (TILs) subdivided into stromal TILs (sTILs) and intratumoral TILs (iTILs) and for four patients representing different mutational patterns. Each bar represents mean and standard error of counts in the tumor areas indicated. For each region, five 40 × HPFs were counted