Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 23;72(6):1603–1618. doi: 10.1007/s00262-022-03346-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — Heterogeneity of immune cell populations in the CD8 + TIL microenvironment in ccRCC. Representative microphotographs of a multiplex immunofluoresence staining for the markers indicated. White lines indicate the nearest immune cell neighbor for each CD8 + TIL. Scale bar = 250 μm (A). Quantification of the number of CD8 + TILs within a 20 μm radius of CD4 + , FOXP3 + or CD68 + immune cells for four ccRCC patients with different mutational patterns. Each bar represents mean and standard error of CD8 + cells obtained from three images analyzed for the different tumor regions with the exception of patient 11, where two images per region were analyzed. IM, invasive margin; TP, tumor periphery; TC, tumor center (B)