Table 2:
Baseline characteristics and changes over a year in DXA variables including body composition and bone parameters for subjects with obesity (OB) and normal-weight controls (NWC)
| Anthropometric Measures | BL OB | BL NWC | p value controlling for age and race | Changes over one year in OB | Changes over one year in NWC | p-value controlling for age and race | p-value controlling for age, race and change in BMI |
|---|---|---|---|---|---|---|---|
| Height, cm | 164.2 (160.7, 168.4) | 163.7 (158.4, 168.6) | 0.959 | 0.4 (−0.2, 0.7) | 0.3 (−0.2, 0.6) | 0.542 | - |
| Weight, kg | 116.1 (98.8, 128.7) | 56.1 (53.7, 60.1) | <0.0001 | 1.3 (−2.3, 4.9) | 0.5 (−0.5, 2.1)# | 0.551 | - |
| BMI, kg/m2 | 41.6 (38.1, 46.7) | 21.2 (20.1, 22.6) | <0.0001 | 0.0 (−0.7, 1.7) | 0.1 (−0.2, 0.7) | 0.526 | - |
| DXA Body Composition | |||||||
| Total Lean Mass, kg | 57.92 ± 1.57 | 40.11 ± 0.56 | <0.0001 | 1.16 ± 0.48# | −0.08 ± 0.17 | 0.030 | - |
| Total Fat Mass, kg | 58.04 (46.59, 63.72) | 15.98 (14.42, 17.37) | <0.0001 | 0.04 (−2.83, 3.11) | −0.16 (−0.74, 1.20) | 0.042 | - |
| Percent Fat Mass, % | 48.80 (45.09, 51.22) | 28.21 (25.58, 31.13) | <0.0001 | −0.68 (−2.33, 0.82) | −0.19 (−1.09, 1.19) | 0.182 | - |
| DXA Bone Variables | |||||||
| Lumbar Spine BMD, g/cm2 | 1.08 ± 0.02 | 0.96 ± 0.01 | <0.0001 | 0.016 ± 0.009 | 0.014 ± 0.004# | 0.925 | 0.912 |
| Lumbar Spine BMD Z scores | 0.80 (0, 1.55) | −0.5 (−1.2, 0) | <0.0001 | 0.00 (−0.25, 0.30) | 0.00 (−0.10, 0.20) | 0.907 | 0.987 |
| Total Hip BMD, g/cm2 | 1.15 ± 0.03 | 0.98 ± 0.01 | <0.0001 | −0.001 ± 0.008 | 0.009 ± 0.003# | 0.030 | 0.076 |
| Total Hip BMD Z scores | 1.70 (0.80, 2.55) | 0.20 (−0.59, 0.88) | <0.0001 | −0.10 (−0.30, 0.15) | 0.03 (−0.10, 0.20)# | 0.018 | 0.046 |
| Femoral Neck BMD, g/cm2 | 1.04 ± 0.03 | 0.85 ± 0.01 | <0.0001 | −0.002 ± 0.012 | 0.006 ± 0.004 | 0.557 | 0.964 |
| Femoral Neck BMD Z scores | 1.65 ± 0.26 | −0.17 ± 0.12 | <0.0001 | −0.10 ± 0.12 | 0.06 ± 0.05 | 0.385 | 0.694 |
| Whole Body BMD, g/cm2 | 1.07 (1.00, 1.13) | 1.04 (1.00, 1.12) | 0.883 | 0.017 (−0.018, 0.035) | 0.001 (−0.012, 0.022) | 0.094 | 0.145 |
| Whole Body BMD Z scores | −0.05 ± 0.26 | −0.42 ± 0.14 | 0.660 | 0.03 ± 0.14 | −0.10 ± 0.05# | 0.091 | 0.139 |
Data presented as mean ± SEM or median (interquartile range)
Significant p values of <0.05 are bolded
*
Signifies reversal in the directionality of the relationship between the groups after adjusted analyses
#
Signifies significant within-group change over one year
BMD: Bone Mineral Density. BMI: Body Mass Index