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. 2023 May 3;10(5):ofad230. doi: 10.1093/ofid/ofad230

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© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Modeled (95% confidence interval [CI]) reduction in the risk of a severe non-AIDS event or death as a result of an increase in antiretroviral therapy (ART) adherence (ie, intervention) based on a Cox proportional hazard model by Grund et al [20]. A, Risk reduction based on data from the Multicenter AIDS Cohort Study that used self-reported adherence. B, Risk reduction based on data from observational cohorts in Africa and interventional clinical trials that used self-reported adherence and electronic adherence monitoring. Solid black lines represent predicted risk reductions (eg, 10%, 20%). Filled squares represent the estimate, and the colored lines represent the 95% CI for each estimate. Open squares represent the 95% CI upper and lower limits of the estimated risk reduction with their corresponding 95% CI. Uganda Aids Rural Treatment Outcomes (UARTO) 10% and UARTO 20% increase represent a 10% and 20% increase in ART adherence, respectively. Adapted from Grund et al [20]. Abbreviations: CI, confidence interval; IL-6, interleukin 6; MACS, Multicenter AIDS Cohort Study; META, Monitoring of Early Treatment Adherence; SMART, Strategies for Management of Antiretroviral Therapy; SNAE, severe non-AIDS event; START, Strategic Timing of Antiretroviral Therapy; UARTO, Uganda Aids Rural Treatment Outcomes.