Table 3.
Estimated a Number of Virally Suppressed Persons With HIV on Antiretroviral Therapy (ART) Who Would Need to Reduce ART Adherence From 100% to <100% to Observe an Additional Severe Non-AIDS Event or Death Over 3 and 5 Years Based on the Change in Plasma Interleukin 6
| Change in IL-6 Driven by a Decrease in ART Adherence | 3-Year Follow-up | 5-Year Follow-up |
|---|---|---|
| 2% increase | 1,001 PWH | 637 PWH |
| 12% increase | 254 PWH | 165 PWH |
| 22% increase | 146 PWH | 95 PWH |
Changes in plasma IL-6 represent the model-estimated 95% confidence interval levels from the Multicenter AIDS Cohort Study [11].
Abbreviations: ART, antiretroviral therapy; IL-6, interleukin 6; PWH, people with human immunodeficiency virus.
a
Assumes that PWH who achieve viral suppression are 100% adherent to ART but that a decrease in adherence—without the development of viremia—is expected in some patients.