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. 2023 May 13;28:61–73. doi: 10.1016/j.bioactmat.2023.04.026

Fig. 2.

Fig. 2

In a bovine meniscus explant healing model via timely controlled delivery of CTGF and TGFβ3, FibGen significantly enhanced healing as compared to fibrin (A) (PR: Picrosirius Red; Saf-O: Safranin O; arrows indicate healing zone; boxes show high magnification). In addition, FibGen significantly increased tensile modulus and strength (B) (*:p < 0.0001; n = 5 per group). Effective indentation moduli (EEff) measured with nanoindentation show a more even distribution (C) and higher average value (D) with FibGen compared to fibrin (*:p < 0.001; n = 25 per group).