Fig. 9.

Speculated mechanism for synergistic effect of heparin conjugation and CD44 incorporation on yielding strong binding to HA- and lubricin-coated meniscus surface. Although specific binding domain, mechanism, and affinity between each other components have been incompletely described, the cross-binding affinity between HA, lubricin, fibrinogen, heparin, and CD44 may have potential to achieve a strong initial binding of our bioactive glue on HA/lubricin-deposited meniscus surface.