Figure 6.

Characterization and annotation of cell states

(A) UMAP visualization of the clustering based on snRNA-seq, snATAC-seq, and WNN analysis before cell state annotation.

(B) Pseudotime single cell trajectory plot. The heatmap represents units of progress, with 1 located at the root of the trajectory.

(C) Cell states derived from pseudotime trajectory inference. State 2 and state 4 are marked NA (not assigned), since they may represent transitioning states and could not be unambiguously assigned to a specific developmental stage.

(D) UMAP visualization of cell states after annotated clustering.