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. 2023 May 9;63:102739. doi: 10.1016/j.redox.2023.102739

Fig. 8.

Fig. 8

Role of Drp1 on mitochondrial fragmentation and mitochondrial dysfunction induced by AgNPs in HT22 cells. HT22 cells were pretreated with/without Mdivi-1 (5 μM) 2 h before exposure to 8 μg/mL AgNPs for 24 h. (A) Alteration of Mitotracker fluorescence in HT22 cells; (B–C) Intracellular ROS levels in HT22 cells; (D–E) MMP changes in HT22 cells; (F) ATP content in HT22 cells. Data are expressed as mean ± SD from three independent experiments. *p < 0.05, **p < 0.01 when compared with the control. #p < 0.05, ##p < 0.01 when compared with the AgNPs (8 μg/mL) group.