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. 2023 May 9;63:102739. doi: 10.1016/j.redox.2023.102739

Fig. 9.

Fig. 9

Role of Drp1-mediated mitochondrial fission on apoptosis induced by AgNPs in HT22 cells. HT22 cells were pretreated with/without Mdivi-1 (5 μM) 2 h before exposure to 8 μg/mL AgNPs for 24 h. (A) Immunofluorescence of Drp1in HT22 cells; (B–C) Western blot for protein expression of Drp1, p-Drp1, Fis1, Mfn1, Mfn2, OPA1 in HT22 cells; (D–E) Apoptosis rate of HT22 cells; (F–G) Western blot for protein expression of Bax, Bcl-2, Caspase-3, Cyt-C in HT22 cells. Data are expressed as mean ± SD from three independent experiments. *p < 0.05, **p < 0.01 when compared with the control. #p < 0.05, ##p < 0.01 when compared with the AgNPs (8 μg/mL) group.