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. Author manuscript; available in PMC: 2023 May 20.
Published in final edited form as: Chem Rev. 2022 Jul 11;122(14):11974–12045. doi: 10.1021/acs.chemrev.2c00106

Figure 27.

Figure 27.

Summary of H2ase-inspired (μ-thiolato)diiron enzymes. (a) Synthetic process for the formation of Cc-bound [Fe(CO)3-(μ-SCys)2-Fe(CO)3] and (b) ensuing H2 production system.320 Reproduced with permission from ref 320. Copyright 2011 Royal Society of Chemistry. (c) Synthetic process for the formation of Pep-18 [Fe(CO)3-(μ-SCys)2-Fe(CO)3] with bound Ru(bpy)3 and (d) ensuing H2 production assay system.321 Reproduced with permission from ref 321. Copyright 2012 Elsevier. (e) Model of the [Fe(CO)3-(μ-SCys)2-Fe(CO)3] binding single-stranded α-helical maquette containing the dithiol UAA “Dt”.322 Reproduced with permission from ref 322. Copyright 2012 Royal Society of Chemistry. (f) Proposed schematic for [Fe4S4]-[Fe2(CO)3(CN)2(adt)] bridge formation in the FdM maquette.323 Reproduced with permission from ref 323. Copyright 2019 Royal Society of Chemistry. (g) Binding of a [Fe(CO)3-(μ-SCys)2-Fe(CO)3]-maleimide complex in the β-barrel protein nitrobindin.324 Reproduced with permission from ref 324. Copyright 2014 American Chemical Society.