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. Author manuscript; available in PMC: 2023 May 20.
Published in final edited form as: Chem Rev. 2022 Jul 11;122(14):11974–12045. doi: 10.1021/acs.chemrev.2c00106

Figure 4.

Figure 4.

Crystal structures of the V21C/V66C/F46S Mb variant (PDB ID: 5ZEO).111 The disulfide bond between the Cys21 and Cys66 residues is highlighted in the red dashed circle. The hydrogen bonds involving the distal His64 and the Ser46 residues are shown by black dashed lines.