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. Author manuscript; available in PMC: 2023 May 20.
Published in final edited form as: Chem Rev. 2022 Jul 11;122(14):11974–12045. doi: 10.1021/acs.chemrev.2c00106

Figure 51.

Figure 51.

(a) Crystal structure of FeBII-V68E/I107ECuBMb (PDB ID: 3M39).529 (b) Cartoon showing that incorporation of the Glu residue near the active site facilitates the proton transfer from the external solvent to the active site, which results in lower KSIE. (c) Structure of the active site of oxy-I107E-CuBMb (PDB ID: 7L3Y).530 (d) Rates of O2 consumption yielding water (blue) or reactive oxygen species (ROS) (red). Parts c and d are reprinted with permission from ref 530. Copyright 2021 American Chemical Society.