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. Author manuscript; available in PMC: 2023 May 20.
Published in final edited form as: Chem Rev. 2022 Jul 11;122(14):11974–12045. doi: 10.1021/acs.chemrev.2c00106

Figure 9.

Figure 9.

(a) Crystal structure of yeast iso-1 Cc (top, PDB ID: 2YCC).147 The flexible coordination loop, Ω-loop D, is colored in red. At the bottom is the multiple sequence alignment of the distal heme region of some classical peroxidases which is compared to the sequence of the distal heme region of yeast iso-1 Cc.154 (b) Substrate recognition sites (SRSs) in P450 enzyme (CYP2C9, PDB ID: 1R9O)155 shown by arrows: SRS1 (red), SRS2 (green), SRS3 (blue), SRS4 (yellow), SRS5 (orange), SRS6 (magenta).156