Figure 2.

ZNF593-AS attenuates diabetes-induced cardiac dysfunction

(A) Schematic of the strategy used for ZNF593-AS deletion. (B, C, and D) Echocardiographic analysis and hemodynamic parameters of ZNF593-AS KO and WT mice fed with high-fat or normal diet: EF value, FS value (B), E/A ratio (C), dp/dt_max and dp/dt_min (D). (E and F) Immunostaining of TUNEL staining in the hearts of ZNF593-AS KO and WT mice fed with high-fat or normal diet. (G) Schematic of the strategy used for ZNF593-AS cardiomyocyte-specific Tg mice construction. (H, I, and J) Echocardiographic analysis and hemodynamic parameters of ZNF593-AS Tg and WT mice fed with high-fat or normal diet: EF value, FS value (H), E/A ratio (I), dp/dt_max, and dp/dt_min (J). (K and L) Immunostaining of TUNEL staining in the hearts of ZNF593-AS Tg and WT mice fed with high-fat or normal diet. One-way ANOVA with the Tukey post-test was used for comparisons.