Table 2. Spearman’s rho correlations between effusion synovitis and synovial fluid biomarkers.

COMP, cartilage oligomeric matrix protein; CTX-II, C-terminal crosslinked telopeptide of type II collagen; IL, interleukin; MMP, matrix metalloproteinase; NTX-I, N-terminal crosslinked telopeptide of type I collagen; sGAG, sulfated glycosaminoglycan

Synovial Biomarker	Effusion-Synovitis Rho	p
Enzyme Concentrations
MMP-1	0.50	0.003
MMP-3	0.63	< 0.001
MMP-9	-0.11	0.52
Cytokine Concentrations
IL-1α	-0.17	0.35
IL-1β	-0.10	0.56
IL-1RA	0.24	0.16
Cartilage Degradation
COMP	-0.18	0.32
CTX-II	-0.05	0.77
sGAG	0.42	0.01
Bony Remodeling
NTX-I	19.7 ± 9.8	0.68
Hemarthrosis
Bilirubin+Biliverdin	0.11	0.53