Table 1.
Left ventricular echocardiographic measurements in male and female mice
| Echocardiographic measurement | Air wild-type | Nicotine wild-type | Air α7-nAChR−/− | Nicotine α7-nAChR−/− |
|---|---|---|---|---|
| Males | n=15 | n=20 | n=7 | n=11 |
| LVID;s (mm) | 2.68 ± 0.10 | 2.63 ± 0.07 | 2.55 ± 0.15 | 2.52 ± 0.11 |
| LVID;d (mm) | 3.88 ± 0.10 | 3.87 ± 0.07 | 3.79 ± 0.20 | 3.81 ± 0.10 |
| LVPW;s (mm) | 1.29 ± 0.03 | 1.18 ± 0.06 | 1.18 ± 0.06 | 1.17 ± 0.04 |
| LVPW;d (mm) | 0.92 ± 0.03 | 0.83 ± 0.03 | 0.86 ± 0.06 | 0.82 ± 0.02 |
| EF (%) | 58.3 ± 2.91 | 60.9 ± 1.55 | 61.6 ± 2.41 | 63.4 ± 2.41 |
| FS (%) | 30.8 ± 1.96 | 32.3 ± 1.10 | 32.7 ± 1.72 | 34.0 ± 1.47 |
| Females | n=8 | n=10 | n=8 | n=11 |
| LVID;s (mm) | 2.76 ± 0.07 | 2.55 ± 0.05 | 2.56 ± 0.18 | 2.56 ± 0.07 |
| LVID;d (mm) | 3.80 ± 0.05 | 3.68 ± 0.04 | 3.75 ± 0.10 | 3.68 ± 0.05 |
| LVPW;s (mm) | 1.02 ± 0.02 | 1.06 ± 0.04 | 1.08 ± 0.04 | 1.02 ± 0.03 |
| LVPW;d (mm) | 0.79 ± 0.02 | 0.77 ± 0.04 | 0.73 ± 0.02 | 0.73 ± 0.01 |
| EF (%) | 53.7 ± 2.52 | 59.3 ± 1.43 | 60.4 ± 4.36 | 58.7 ± 1.97 |
| FS (%) | 27.4 ± 1.70 | 30.9 ± 0.96 | 32.3 ± 3.14 | 30.5 ± 1.28 |
Data are displayed as mean ± SEM and analyzed by two-way ANOVA; EF, ejection fraction; FS, fractional shortening; LV, left ventricle; LVID;s/d, LV internal diameter during systole/diastole; LVPW;s/d, LV posterior wall thickness during systole/diastole.