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. 2023 May 19;23:464. doi: 10.1186/s12885-023-10882-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Treg cells show positive correlation with CD8 + T cells in gastric cancer. (A) Pearson’s correlation coefficient revealed a positive correlation between FOXP3 and CD8A expression in TCGA database. (B) Pearson’s correlation coefficient revealed a positive correlation between CD4 and CD8A expression in TCGA database. (C) Pearson’s correlation coefficient revealed a positive correlation between CD25 and CD8A expression in TCGA database. (D) Flow cytometry assay showed positive correlation between Treg cells and CD8 + T cells in 20 fresh gastric cancer samples. (E) KMplotter database demonstrated that patients with high FOXP3 expression had worse overall survival than those with low FOXP3 expression