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. 2023 May 19;23:464. doi: 10.1186/s12885-023-10882-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Chemokine CCL19 has strong chemotactic activity on Treg cells. (A) Relative CCL19 mRNA expression in 32 pairs of cancerous and noncancerous tissues from gastric cancer patients in TCGA database. (B-C) Immunofluorescence staining showed that the percentage of CCL19 + cells were positively correlated with the percentage of FOXP3 + cells in gastric cancer tissues. (D-E) Transwell experiment showed that the number of migrated CD8 + T cells was slightly increased in supernatant containing chemokine CCL19. (F-G) Transwell experiment showed that the number of migrated Treg cells was remarkably increased in supernatant containing chemokine CCL19. (H) Survival analysis of gastric cancer patients in TCGA database demonstrated that the patients with high CCL19 expression had worse overall survival than those with low CCL19 expression. Values are mean ± s.d., *P < 0.05 (Student’s t-test)