Table 9.
Univariate and multivariate analyses model analyzed predictors of successful conversion in 809 patients.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Age (years, < 65 vs ≥65) | 0.629(0.213~1.86) | 0.402 | ||
| Sex (female vs male) | 0.95(0.281~3.212) | 0.935 | ||
| ECOG PS (0~2 vs 3~4) | 0.049(0.022~1.229) | 0.769 | ||
| BCLC staging (A~B vs C~D) | 1.134(0.435~2.953) | 0.797 | ||
| Child-Pugh classification (A~B vs C) | 0.384(0.051~2.883) | 0.838 | ||
| Number of tumors (solitary vs multiple) | 0.391(0.166~0.921) | 0.032 | 0.738(0.278~1.956) | 0.541 |
| Tumor size (cm, ≤10 vs >10) | 3.077(1.296~7.302) | 0.011 | 2.484(0.892~6.92) | 0.082 |
| AFP(ng/ml,≤400 vs >400) | 2.122(0.796~5.653) | 0.133 | 2.099(0.766~5.751) | 0.15 |
| HBV (no vs yes) | 0.451(0.16~1.268) | 0.131 | 0.63(0.218~1.815) | 0.63 |
| ALT (u/L,≤40 vs >40) | 0.704(0.264~1.876) | 0.483 | ||
| AST(u/L, ≤35 vs >35) | 2.375(0.687~8.204) | 0.172 | 2.132(0.575~7.905) | 0.257 |
| Bilirubin(umol/L, ≤35 vs >35) | 0.042(0~29.086) | 0.342 | ||
| Albumin (g/L, ≤35 vs >35) | 0.94(0.272~3.248) | 0.922 | ||
| Liver cirrhosis (no vs yes) | 0.165(0.06~0.454) | <0.001 | 0.291(0.098~0.869) | 0.027 |
| PVTT (no vs yes) | 1.18(0.489~2.85) | 0.713 | ||
| HVTT (no vs yes) | 2.501(0.58~10.782) | 0.219 | ||
| IVCTT (no vs yes) | 0.045(0~93.26) | 0.425 | ||
| Ascites (no vs yes) | 0.229(0.053~0.987) | 0.048 | 0.259(0.056~1.206) | 0.085 |
| Intrahepatic metastasis (no vs yes) | 0.301(0.04~2.25) | 0.242 | ||
| Extrahepatic metastasis (no vs yes) | 0.148(0.054~0.993) | 0.063 | 0.181(0.024~1.378) | 0.099 |
| lymphatic metastasis (no vs yes) | 0.672(0.252~2.012) | 0.478 | ||
| Treatment (LR+TKI/anti-PD-1 vs LR+TKI+anti-PD-1) | 1.71(0.584~5.002) | 0.328 | ||
The association between successful conversion and those baseline stratification tactors, including age, sex, ECOG, BCLC staging, Child-Pugh classification, number of tumors, tumor size, serum AFP level, HBV infection, ALT, AST, bilirubin, albumin, liver cirrhosis, PVTT, HVTT, IVCTT, ascites, Intrahepatic metastasis, lymphatic metastasis, extrahepatic metastases and treatment methods, respectively, was analyzed by Cox proportional-hazards model to generate crude HRs and 95% Cls. Variables with P < 0.2 in univariate analysis were included in multivariate regression analysis model. P < 0.05 was considered to indicate a statistically significant
BCLC Barcelona Clinic Liver Cancer Staging System, PVTT Portal vein tumor thrombus, HVTT Hepatic vein tumor thrombus, IVCTT Inferior vena cava tumor thrombus, LR Loco-regional therapy