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. 2023 May 20;21:159. doi: 10.1186/s12951-023-01900-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — CNPs enhanced anti-tumor activity of anti-PD1 antibody (aPD1). (A) Treatment and analysis schedule. (B) Tumor growth curve. (C) INF-γ secretion in sera. (D) The infiltration of CD3⁺CD4⁺ T cells in tumor tissues. (E) The infiltration of CD3⁺CD8⁺ T cells in tumor tissues. (F) Tumor growth curves. (G) INF-γ secretion in sera. The data were presented as means ± s.d. Statistical significance was calculated by one-way analysis of variance (ANOVA). (n = 5), *, P < 0.05; **, P < 0.01