Table 4.
The Ongoing Clinical Trials Investigating MSCs for IBD
| NCT Number | Sponsor Country | Phase | Clinical Indication | SC Sources | MSC Dose (Cells) | Administration Route | Status |
|---|---|---|---|---|---|---|---|
| 03299413 | Jordan | I/II | IBD | W. Jelly MSCs | 1.2×109 cells | iv. | Active |
| 03115749 | Montpellier | N/A | IBD | Intestinal MSCs | N/A | N/A | No recruiting |
| 01914887 | Spain | I/II | UC | Allogeneic ASCs | 6×107 cells | Colonoscope | Recruiting |
| 01874015 | Spain | I | CD | BM-MSCs | N/A | N/A | Recruiting |
| 01157650 | USA | I/ II | CD | Autologous MSCs | N/A | N/A | Completed |
| 00294112 | USA | II | CD | Adult human MSCs | 2, 8×106 cells | iv. | Completed |
| 02677350 | USA | I | CD | BM-MSCs | 2×107 cells | iv. | Withdrawn |
| 02445547 | China | I/II | CD | UCBSCs | 1×106 cell/kg | iv. | Completed |
| 00543374 | USA | III | CD | PROCHYMAL® | 0.6–1.2×109 cells | iv. | Completed |
| 00482092 | USA | III | CD | MSCs | 0.6–1.2×109 cells | iv. | Completed |
| 01540292 | Belgium | I/II | CD | MSCs | 1.5–2 ×106 cell/kg | iv. | Unknown status |
| 04519671 | USA | I/II | CD | BM-MSCs | 7.5×107 cells | iv. | Recruiting |
| 04519684 | USA | I/II | CD | BM-MSCs | 7.5×107 cells | iv. | Recruiting |
| 01144962 | USA | I/II | PFCD | BM-MSCs | 1–9×107 cells | Local injection | Completed |
| 04519697 | Nether-land | I/II | PFCD | MSCs | 7.5×107 cells | Local injection | Recruiting |
| 04073472 | USA | I | PFCD | BM-MSCs | 6×107 cells | Local injection | No recruiting |
| 04548583 | USA | I/II | CD | BM-MSCs | 1.5–3×108 cells | Endoscopic | Recruiting |
| 03183661 | China | I | CD | Allogenic-ASCs | 2, 8×106 cell/ kg | iv. | Enrolling |
| 01221428 | Austria | I/II | UC | UCBSCs | 2×107 cells | iv. | Unknown |
| 01541579 | Austria | III | PFCD | ASCs | 1.2×108 cells | Local injection | Completed |
| 04312113 | USA | I | UC | Autologous-ASCs | 1.5–3×107 cells | Intraarterial | Recruiting |
| 04543994 | USA | I/II | UC | BM-MSCs | 1.5, 3×108 cells | Endoscopic | Recruiting |
| 01233960 | USA | III | UC | MSCs | 2×108 cells | Intraarterial | Completed |
| 03609905 | China | I/II | UC | ASCs | 5×107 cells | Colonoscope | Recruiting |
| 03901235 | Belgium | I/II | N/A | MSCs | N/A | Local injection | Recruiting |
| 02442037 | China | I/II | UC | UCBSCs | 1×106 cell/kg | iv. | Recruiting |
| 02580617 | Korea | I | CD | ASCs | 0.15–1×108 cells | N/A | Recruiting |
| 01510431 | USA | N/A | CD | MSCs | 2×108 cells | N/A | Not available |
| 02403232 | Italy | II | CD | ASCs | N/A | N/A | Recruiting |
| 02403232 | Korea | I/II | CD | UCBSCs | 0.5, 1×108 cells | iv. | Unknown status |
| 02926300 | Korea | I/II | CD | SCs | Not provided. | N/A | Recruiting |
| 03220243 | USA | I | PFCD | MSCs | 2×107 cells | Local injection | Completed |
| 01915927 | USA | I | PFCD | MSCs | 2×107 cells | Local injection | Completed |
| 03449069 | USA | I | PFCD | MSCs | 2×107 cells | Local injection | Recruiting |
Abbreviations: ASCs, adipose mesenchymal stem cells; BM-MSCs, Bone marrow mesenchymal stem cells; CD, Crohn’s disease; IBD, Inflammatory bowel disease; iv., intravenous injection; MSCs, mesenchymal stem cells; PFCD, perianal fistula Crohn’s disease; PROCHYMAL®, Human Adult stem cells; SCs, stem cells; UC, Ulcerative colitis; UCBSCs, Umbilical Cord Blood stem cells; USA, United States, N/A, Not provided, W. Jelly, Wharton Jelly.