Table 6.
Binding affinity values of selected antiviral drugs in clinical trials to treat COVID-19, binding with different SARS-CoV-2 related receptors. The ranks are listed among 85 antiviral drugs*
| Drug Name | # Clinical | # Supporting | Spike-ACE2 | helicase | 3C-like | RdRp | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Trial | References | pIC50 | rank | pIC50 | rank | pIC50 | rank | pIC50 | rank | |
| Atazanavir | 3 | 6 | 6.89 | 36 | 6.36 | 32 | 6.18 | 23 | 6.10 | 21 |
| Daclatasvir | 8 | 5 | 7.23 | 24 | 6.57 | 21 | 6.88 | 7 | 6.85 | 6 |
| Danoprevir | 2 | 3 | 7.57 | 10 | 5.68 | 54 | 6.46 | 17 | 5.71 | 33 |
| Darunavir | 2 | 6 | 6.40 | 50 | 6.72 | 15 | 5.85 | 39 | 6.05 | 24 |
| Elvitegravir | 7 | 2 | 7.43 | 14 | 7.28 | 3 | 7.06 | 5 | 6.61 | 12 |
| Lopinavir | 39 | 26 | 7.44 | 12 | 5.55 | 60 | 5.26 | 60 | 5.18 | 53 |
| Oseltamivir | 9 | 5 | 6.75 | 41 | 5.24 | 70 | 5.27 | 59 | 5.12 | 57 |
| Remdesivir | 67 | 70 | 7.47 | 11 | 6.00 | 44 | 5.68 | 43 | 6.00 | 26 |
| ritonavir | 57 | 27 | 7.16 | 26 | 7.01 | 6 | 6.62 | 11 | 6.96 | 3 |
*The information on the number of clinical trials and supporting references are gathered from https://covid19-help.org/ as of July 2022.