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UniDesign computed total versus binding energy for all PAM variants on different Cas protein scaffolds. (A) 4UN3 (SpCas9); (B) 5F9R (SpCas9); (C) 5AXW (SaCas9); (D) 5CZZ (SaCas9); (E) 6M0W (St1Cas9); (F) 5B2O (FnCas9); (G) 6JDV (Nme1Cas9); (H) 6JE3 (Nme2Cas9); (I) 6JOO (CdCas9); (J) 6WBR (AceCas9); (K) 5B43 (AsCas12a) and (L) 5XUS (LbCas12a). The variants with consensus PAMs are colored in red while the others are in gray. UEU, UniDesign energy units.
