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. 2023 Mar 24;24(3):bbad119. doi: 10.1093/bib/bbad119

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Performance of pan-cancer exosome purity model evaluated in simulated data and actual data. The PC between simulated and predicted exosome purity for all samples with the tumour purity ranging from 0 to 1 (A) and from 0 to 0.1 (B) in pan-cancer exosome purity model. (C) Comparison of the predicted tumour purity between cancer cell line-derived exosomes (left bars) and healthy controls (right bars) for all samples. (D) Comparison of the predicted tumour purity with 11 individual cancer signatures and pan-cancer signatures for 11 different cancer cell line-derived samples. The P value is calculated with the Wilcoxon rank-sum test. The PC between the simulated and predicted tumour purity ranging from 0 to 1 (E) and from 0 to 0.1 (F) when the different levels of noise added. The Kaplan–Meier curve illustrates the probability of OS according to the average expression levels of the 28 down-regulated miRNAs in breast cancer (G) and lung cancer (H).