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. 2023 May 20;13:8175. doi: 10.1038/s41598-023-35485-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Modulation of AGTR1 mRNA expression following demethylation in HEK 293 cells. HEK 293 cells were treated for 72 h with various concentration of 5-aza-2′-deoxycytidine. After treatment, demethylation of AGTR1 promoter CpG site (cg10297223) was confirmed by pyrosequencing analysis (a) and the expression of AGTR1 mRNA was measured by RT-qPCR (b). Data are presented as the mean ± SD from three independent experiments. Statistical analyses were performed using one-way ANOVA with Dunnett’s multiple comparison post-test for comparing significance with untreated control (*P < 0.05, **P < 0.01, ***P < 0.001). 5-aza, 5-aza-2′-deoxycytidine.