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. Author manuscript; available in PMC: 2024 Jan 5.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2023 Jul 5;32(7):927–935. doi: 10.1158/1055-9965.EPI-22-0808

Table 3.

Hazard ratios for the association between night shift work and risk of colorectal cancer, according to strata of age and chronotype.

	Age				Chronotype
	<50 years		≥50 years		Morning		Evening		Neither
Night shift work	Cases/PY	Age-adjusted HR (95% CI)^a	Cases/PY	Age-adjusted HR (95% CI)^a	Cases/PY	Age-adjusted HR (95% CI)^a	Cases/PY	Age-adjusted HR (95% CI)^a	Cases/PY	Age-adjusted HR (95% CI)^a

Never	22/91,893	1.00 (ref)	86/133,593	1.00 (ref)	46/101,220	1.00 (ref)	22/53,772	1.00 (ref)	7/22,407	1.00 (ref)
Ever	17/64,009	1.12 (0.60–2.12)	79/104,291	1.19 (0.87–1.61)	31/70,328	0.97 (0.61–1.53)	24/42,066	1.35 (0.75–2.42)	6/16,288	1.05 (0.35–3.16)
Duration ^b
<5 years	11/45,935	1.01 (0.49–2.07)	45/65,300	1.11 (0.77–1.59)	19/48,199	0.90 (0.53–1.55)	16/27,724	1.42 (0.74–2.73)	^c	–
≥5 year	5/12,880	1.69 (0.64–4.49)	26/28,608	1.37 (0.88–2.13)	8/15,426	1.08 (0.51–2.30)	5/10,913	1.04 (0.39–2.77)	^c	–

PY, Person-years; HR, Hazard ratio; CI, Confidence interval.

^a

Hazard ratios adjusted for age (continuous) and time period (continuous).

^b

Reference group is never worked a night shift.

^c

Hazard ratios are not presented for case counts <5.