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. 2023 May 21;21:335. doi: 10.1186/s12967-023-04187-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Mitochondrial dysfunction increases in CRC cells by treatment with IL-17A. A Transmission electron microscopy of CRC cells after treatment with IL-17A.Arrowheads indicate mitochondria; B CRC cells after treatment with IL-17A were immunostained with Mito-Tracker (red), anti-α-tubulin (green), and DAPI (nuclei, blue); C, D The expression of OxPhos complex subunits in CRC cells after treatment with IL-17A was analysed by western blotting, data conforms to normal distribution, and tested by two independent samples t-test. The mitochondrial membrane potential was measured using JC-1 dye. E representative microscopic and (F-G) flow cytometry analysis and quantitation, data conforms to normal distribution, and tested by two independent samples t-test. Immunostained for the Mitochondrial Superoxide Indicator with Mito-SOX. H representative microscopic and I-J flow cytometry analysis and quantitation, data conforms to normal distribution, and tested by two independent samples t-test