. Author manuscript; available in PMC: 2023 May 21.

Published in final edited form as: Endocr Pract. 2022 Aug 11;28(10):923–1049. doi: 10.1016/j.eprac.2022.08.002

Table 8.

Atherosclerotic Cardiovascular Disease Risk Calculators

ASCVD risk calculators (date)	Atherosclerotic cardiovascular disease risk factors											ASCVD end points^*
	Age	Sex	Family history	Current tobacco use	T2D	SBP		Lipid profile (mg/dL)			Other CVD RFs
	Age	Sex	Family history	Current tobacco use	T2D	mmHg	Rx	TC	HDL-C	Rx^a	Other CVD RFs
Reynolds CVD Risk Score (2007–2008) ^290,291	X	X	X	X	X^b	X		X	X		hs-CRP	1,2,5,7
Framingham CVD Risk Score (2008–2009) ^292,293	X	X		X	X	X	X	X	X			1,2,3,4,6,7,8,9,10
ACC/AHA Pooled Cohort CVD Risk Calculator (2013) ^294,295	X^c	X		X	X	X	X	X	X			1,2,7,8
MESA Risk Score (2015) ²⁹⁶	X^d	X	X^e	X	X	X	X	X	X	X	CAC score	1,2,5^f

Abbreviations: ACC/AHA = American College of Cardiology/American Heart Association; ASCVD = atherosclerotic cardiovascular disease; CAC = coronary artery calcification; CHD = coronary heart disease; CVD = cardiovascular disease; hs-CRP = high-sensitivity C-reactive protein; HDL-C = high-density lipoprotein cholesterol; mm Hg = millimeters mercury; MI = myocardial infarction; RF = risk factor; Rx = treatment; SBP = systolic blood pressure; T2D = type 2 diabetes; TC = total cholesterol

Endpoints: (1) CHD death, (2) nonfatal MI, (3) unstable angina, (4) stable angina, (5) coronary revascularization, (6) heart failure, (7) nonfatal stroke, (8) fatal stroke, (9) transient ischemic attack, (10) claudication

Use of lipid-lowering therapy.

Assessed by A1C value for women only, not for men.

Validated for adults 40–79 years of age.

Included non-Hispanic White, Hispanic, African American, and Chinese American ethnic groups.

Family history of MI at any age.

Also included resuscitated cardiac arrest.