. Author manuscript; available in PMC: 2023 May 21.

Published in final edited form as: Endocr Pract. 2022 Aug 11;28(10):923–1049. doi: 10.1016/j.eprac.2022.08.002

Table 13.

Clinical Symptoms and Signs of Diabetic Peripheral Neuropathy

	Large myelinated nerve fibers	Small nerve fibers
Symptoms	Numbness Tingling Poor balance	Pain: Burning Electric shocks Stabbing pain Hyperalgesia Allodynia
Function	Pressure, balance	Nociception; protective sensation
Examination (clinically diagnostic)^a	Ankle reflexes Reduced Abolished Vibration perception^a Reduced Absent 10-g monofilament^a Reduced Absent Proprioception impaired	Thermal (cold/hot) discrimination^a Reduced Absent Pinprick sensation^a Reduced Absent

Document impairment/loss in symmetrical, distal to proximal pattern