Table 2.
Relationship between caffeine consumption and amyloid positivity in all participants
| Factors | Model 1 adjusted OR (95% CI) | p | Model 2 adjusted OR (95% CI) | p | Model 3 adjusted OR (95% CI) | p |
| Caffeine consumption (ref: no) | 0.96 (0.80, 1.15) | 0.627 | 0.95 (0.78, 1.14) | 0.558 | 0.67 (0.05, 8.30) | 0.752 |
| Female (ref: male) | 1.09 (0.95, 1.25) | 0.217 | 1.09 (0.93, 1.26) | 0.286 | 0.78 (0.55, 1.10) | 0.160 |
| 70–75 y (ref: 65–70 y) | 1.54 (1.31, 1.80) | <0.001 | 1.54 (1.31, 1.80) | <0.001 | 1.56 (1.06, 2.29) | 0.026 |
| 75–80 y (ref: 65–70 y) | 2.30 (1.89, 2.81) | <0.001 | 2.31 (1.88, 2.83) | <0.001 | 2.06 (1.24, 3.40) | 0.005 |
| 80–85 y (ref: 65–70 y) | 2.70 (2.04, 3.58) | <0.001 | 2.72 (2.05, 3.63) | <0.001 | 3.33 (1.71, 6.50) | <0.001 |
| ɛ2/ɛ3 (ref: ɛ2/ɛ2) | 1.06 (0.35, 3.21) | 0.921 | 1.07 (0.35, 3.26) | 0.907 | 1.24 (0.13, 11.66) | 0.853 |
| ɛ2/ɛ4 (ref: ɛ2/ɛ2) | 3.54 (1.12, 11.15) | 0.031 | 3.56 (1.13, 11.25) | 0.032 | 4.12 (0.35, 48.22) | 0.259 |
| ɛ3/ɛ3 (ref: ɛ2/ɛ2) | 1.50 (0.51, 4.44) | 0.467 | 1.51 (0.51, 4.49) | 0.462 | 1.47 (0.17, 12.95) | 0.730 |
| ɛ3/ɛ4 (ref: ɛ2/ɛ2) | 6.41 (2.16, 19.03) | 0.001 | 6.43 (2.16, 19.15) | 0.001 | 5.03 (0.57, 44.54) | 0.146 |
| ɛ4/ɛ4 (ref: ɛ2/ɛ2) | 27.18 (8.43, 87.61) | <0.001 | 27.62 (8.54, 89.31) | <0.001 | 46.66 (3.42, 636.48) | 0.004 |
| Normal weight (ref: underweight) | 1.24 (0.55, 2.80) | 0.605 | 1.22 (0.54, 2.75) | 0.634 | ||
| Overweight (ref: underweight) | 1.20 (0.53, 2.70) | 0.661 | 1.18 (0.53, 2.67) | 0.684 | ||
| Obesity (ref: underweight) | 1.24 (0.55, 2.81) | 0.595 | 1.23 (0.54, 2.78) | 0.621 | ||
| Married (ref: not married) | 1.02 (0.88, 1.19) | 0.772 | 1.02 (0.88, 1.20) | 0.757 | ||
| Education years | 1.01 (0.99, 1.04) | 0.337 | 1.01 (0.99, 1.04) | 0.345 | ||
| Alcohol drinking (ref: no) | 1.05 (0.92, 1.21) | 0.444 | 1.06 (0.92, 1.22) | 0.427 | ||
| Smoking (ref: no) | 0.99 (0.54, 1.82) | 0.999 | 1.00 (0.54, 1.83) | 0.995 | ||
| Psychiatric disorders (ref: no) | 1.11 (0.95, 1.30) | 0.214 | 1.11 (0.94, 1.30) | 0.211 | ||
| Neurological diseases (ref: no) | 1.13 (0.96, 1.33) | 0.147 | 1.13 (0.96, 1.32) | 0.149 | ||
| Cardiovascular diseases (ref: no) | 1.05 (0.91, 1.21) | 0.539 | 1.05 (0.90, 1.21) | 0.551 | ||
| Endocrinological diseases (ref: no) | 1.08 (0.94, 1.24) | 0.287 | 1.08 (0.94, 1.23) | 0.305 | ||
| Caffeine×female | 1.49 (1.02, 2.17) | 0.037 | ||||
| Caffeine×70–75 y | 0.99 (0.65, 1.52) | 0.969 | ||||
| Caffeine×75–80 y | 1.15 (0.66, 1.98) | 0.626 | ||||
| Caffeine×80–85 y | 0.78 (0.37, 1.63) | 0.510 | ||||
| Caffeine×ɛ2/ɛ3 | 0.85 (0.06, 11.30) | 0.903 | ||||
| Caffeine×ɛ2/ɛ4 | 0.85 (0.05, 13.93) | 0.912 | ||||
| Caffeine×ɛ3/ɛ3 | 1.05 (0.08, 12.94) | 0.972 | ||||
| Caffeine×ɛ3/ɛ4 | 1.36 (0.11, 16.83) | 0.813 | ||||
| Caffeine×ɛ4/ɛ4 | 0.56 (0.03, 10.54) | 0.698 |
OR, odds ratio.