Fig. 1.

From tau neuropathology to tau therapeutics. The upper panel illustrates the mechanisms of action potentially shared between tau and mHTT at the cellular level. The bottom panel represents the potential implications of tau on the neuropathology and symptomatology of HD and implying its clinic relevance as a biomarker and/or therapeutic target. Abbreviations: MAPT, microtubule associated protein tau; mHTT, mutant huntintin; NFTs, neurofibrillary tangles; p-tau, phosphorylated tau; SRSF6, serine/arginine-rich splicing factor-6; 3R, 3R isoform of tau; 4R, 4R isoform of tau; Δtau314, truncated tau314 protein.