Table 1.

Supporting and opposing arguments for the role of tau in HD

Discrepancies between studies concerning 1) kinase and phosphatase dysregulations; 2) tau and mHTT interactions; 3) the contribution of tau to HD-like symptomatology and 4) the presence of tau in biofluids. Abbreviations: BDNF, Brain-Derived Neurotrophic Factor; CSF, Cerebrospinal Fluid; GSK3B, Glycogen Synthase Kinase 3 Beta; HD, Huntington's Disease; mHTT, mutant huntintin; p-tau, phosphorylated tau; t-tau, total tau; ↑, increase; ↓ decrease; ✓, presence; ✗, absence.