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Schematic representation of LRRK2 domain structure. Respective locations of the amino acid substitutions previously linked to Parkinson’s disease and inflammatory bowel disease are shown. ARM, armadillo; ANK, ankyrin repeat region; LRR, leucine-rich repeat; ROC, Ras of complex proteins; COR, C terminal of ROC; KIN, mitogen-activated protein kinase; WD40, WD40 protein-protein interaction domain.
